The film "Lewis and Clark" chronicles the historic expedition led by Meriwether Lewis and William Clark, beginning with their departure from St. Louis to explore the newly acquired Louisiana Territory. The story details their journey up the Mississippi River, through encounters with various Native American tribes, including their significant winter stay with the Mandan people in North Dakota. Here, they meet Charbonneau and his Shoshone wife, Sacajawea, who plays a crucial role as a guide and interpreter. The film follows their challenging trek through the Rockies and down the Columbia River, highlighting their scientific discoveries, including observations of natural resources, plants, animals, and topography. The expedition’s struggles and achievements underscore the spirit of exploration, culminating in their successful reach to the Pacific Coast. The film portrays their legacy as pioneers in opening the American West.